Studieoverzicht

Study name: KRASCENDO

Histology	NSCLC, only non-squamous
Tumor stage	Stage III - IV
Host / recruiting site 1	Radboud UMC	Enrollment	Recruiting
Host / recruiting site 2	Antoni van Leeuwenhoek	Enrollment	Recruiting
Therapy line	First line (1L)
Design	This is an open-label, multicenter Phase Ib/II study designed to evaluate the safety, pharmacokinetics and activity of divarasib in combination with other cancer-therapies with untreated advanced or metastatic NSCLC that harbors a KRAS G12C mutation.
Intervention	Cohort A: Divarasib + Pembrolizumab Cohort B: Divarasib + Pembrolizumab + Platinum-based chemotherapy + Pemetrexed
Key inclusion criteria	Unresectable advanced or metastatic KRAS G12C+ NSCLC Non-squamous Treatment naïve
Key exclusion criteria	Known concomitant second driver mutation with available targeted treatment. Squamous cell histology, mixed tumors. Symptomatic, untreated or actively progressing CNS metastases
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