Studieoverzicht
Study name: GO41596
Histology | NSCLC |
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Tumor stage | Stage IV |
Host / recruiting sites | Amsterdam UMC |
Enrollment | Closed |
Therapy line | Later line (≥2L) |
Design |
Open-Label, Multicenter, Global, Dose-Escalation Study |
Intervention | XmAb24306 as a Single Agent and in Combination with Atezolizumab |
Key outcome parameters | Percentage of Participants with Adverse Events |
Key inclusion criteria | 18 Years and older Eastern Cooperative Oncology Group (ECOG) Performance Status of 0 or 1 Life expectancy >/= 12 weeks Adequate hematologic and end-organ function For participants receiving therapeutic anticoagulation: stable anticoagulant regimen Negative serum pregnancy test for women of childbearing potential Histologically confirmed locally advanced, recurrent, or metastatic incurable solid tumor malignancy Measurable disease per Response Evaluation Criteria in Solid Tumors (RECIST) v1.1 Availability of representative tumor specimens |
Key exclusion criteria | Pregnant or breastfeeding, or intending to become pregnant during the study Significant cardiovascular disease Current treatment with medications that prolong the QT interval Known clinically significant liver disease Poorly controlled Type 2 diabetes mellitus Symptomatic, untreated, or actively progressing CNS metastases History of leptomeningeal disease History of malignancy other than disease under study within 3 years prior to screening Active or history of autoimmune disease or immune deficiency Active tuberculosis, hepatitis B, hepatitis C, or known/suspected Epstein Barr virus infection Positive for HIV infection Prior allogeneic stem cell or solid organ transplantation |
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