Studieoverzicht

Study name: UPLAN-1

Histology NSCLC
Tumor stage Stage I - III
Host / recruiting sites MUMC+, UMC Groningen
Enrollment Recruiting
Key inclusion criteria

Inclusion criteria (let op korte versie, zie full protocol voor details)

  • ECOG/WHO performance 0-1
  • Pathologically proven NSCLC, staged according to the 8th edition of the AJCC Staging Manual, with a clinical indication for concurrent CRT
  • Pathology proven N2 or N3 lymph node metastasis
  • The patient is able to receive concurrent CRT. (0=no, 1=yes)
  • The patient is operable to the discretion of the treating pulmonary physician, surgeon and anesthesiologist, based on lung function testing and performance scoring.
Key exclusion criteria

Exclusion criteria

  • Irresectable primary lung tumor before start of concurrent CRT.
  • Pneumonectomy deemed necessary (by the treating surgeon) to achieve a complete resection (R0).
  • Sulcus superior tumor with invasion of the thoracic wall.
  • cT3-4 based on satellite nodus/lesion in the ipsilateral lung.
  • Patients with a locoregional recurrence or a second primary lung cancer.
  • Patients with prior treatment with radiotherapy on the lung.
  • Patients with a history of other malignancies (for exceptions see full protocol)
  • Small cell lung cancer or a pulmonary carcinoid tumor.
Contact information