The purpose of this study is to test the safety and efficacy of BMS-986482 alone and as combination therapy in participants with advanced solid tumors.
Intervention
DRUG: BMS-986482
Specified dose on specified days
DRUG: Nivolumab and rHuPH20
Specified dose on specified days
DRUG: Bevacizumab
Specified dose on specified days
Key inclusion criteria
Participants must have recurrent or progressive disease during or after platinum doublet-based chemotherapy for advanced or metastatic disease, OR must have recurrent or progressive disease within 6 months after completing platinum-based chemotherapy for local disease.
Participants must have received anti-PD-(L)1 therapy, if eligible and available.
Status for actionable mutations (eg, epidermal growth factor [EGFR], anaplastic lymphoma kinase [ALK], ROS oncogene 1 [ROS1], rearranged during transfection [RET], etc.) must be known (when testing is available as per country/region standard of care practices); participants with actionable mutations must have received and progressed on, have been intolerant to, or not be a candidate for standard tyrosine kinase inhibitors (as available per country/region standard-of-care practices).
Key exclusion criteria
History of life threatening immune mediated toxicity related to prior T-cell agonist or checkpoint inhibitor therapy, except those that are unlikely to re-occur with standard countermeasures.
Untreated or symptomatic central nervous system (CNS) metastases. Participants are eligible if CNS metastases have been treated and participants have neurologically returned to baseline (except for residual signs or symptoms related to the CNS treatment). In addition, participants must have been either off corticosteroids, or on a stable or decreasing dose of ≤ 10 mg QD prednisone (or equivalent) for at least 2 weeks prior to treatment assignment.
History of medically significant thromboembolic events or bleeding diathesis within the past 6 months, eg, cerebrovascular accident (including transient ischemic attacks), pulmonary hemorrhage > 2 teaspoonfuls/24 hours or repeated pulmonary hemorrhage, or gastrointestinal hemorrhage requiring transfusion or procedural intervention.
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